Mitochondrial DNA haplogroups and age at onset of schizophrenia

Mitochondrial DNA haplogroups and age at onset of schizophrenia 
Magri C, Gardella R, Barlati SD, Valsecchi P, Sacchetti E, Barlati S. 2007. Mitochondrial DNA Haplogroups and Age at Onset of Schizophrenia. Am J Med Genet Part B 144B:496-501.

A number of studies support a possible link between mitochondrial dysfunction and schizophrenia. To test the hypothesis of a direct contribution of mitochondrial DNA (mt-DNA) in susceptibility to DSM-IV-TR-schizophrenia, we looked for differences in the frequency distribution of the major European haplogroups (hgs) in 142 patients and 190 controls both of Italian origin. A subgroup of patients (N = 37) and healthy counterparts (N = 41) was also analyzed for possible differences in the relative amount of mt-DNA versus nuclear-DNA in blood cells. Patients and controls were comparable for hg frequency distribution and the relative levels of mt-DNA even after stratification by gender and schizophrenia subtype. However, patients harboring the hg J-T showed an anticipated onset of the disorder. These results indicate that the J-T hg of mt-DNA may have a modulator effect on deeper determinants of schizophrenia.

Yet again mt DNA has an affect on health.


One response to “Mitochondrial DNA haplogroups and age at onset of schizophrenia

  1. It doesn’t say directly that mtDNA has a direct effect on schizophrenia, though it may be the case, but that certain matrilineal lineages (JT) are more prone to an early onset of the psychopathy. The effect may be inherited by some other gene(s), like within the X chromosome (it does statistically appear earlier among men too, what may indicate an X-DNA factor in action here).

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