Suraksha Agrawal1,*, Faisal Khan1, Atul Pandey1, Manorama Tripathi1 and Rene J. Herrera2
YAP, an Alu insertion polymorphism found on human Y-chromosome is present in two lineages worldwide, corresponding to M145/M203/SRY4064 (haplogroup E) and M145/M203/M174 (haplogroup D) polymorphisms respectively. First lineage belonging to haplogroup D is specific to Japan and other Southeast Asian populations, while haplogroup E is confined to Sub-Saharan African, Middle Eastern and Southern European populations. In the present study, 1021 Y-chromosomes belonging to nine different populations of North India were analysed for YAP insertion and four other single nucleotide polymorphisms (SNPs) to delineate the two lineages. Out of nine populations only one, i.e. Shiya Muslims revealed presence of YAP element at a frequency of 11%. Further analysis based on four additional SNPs revealed that all the YAP+ve samples could be categorized under African/Middle East-specific haplogroup E lineage. Interestingly, Sunni Muslims who historically have the same origin, i.e. from the Middle east showed a complete lack of YAP+ve lineage similar to other castes. We hypothesize that unlike Sunnis, Shiya Muslims due to their lesser number and less admixture with other caste groups of India, still carry the ancestral YAP+ve lineage, which in all probabilities is one of the founder haplogroups. All Middle Eastern populations show the presence of this lineage in almost similar frequency. Our study shows the presence of YAP+ve lineage in North Indian populations, reflecting an African/Middle Eastern migration into North India
This week’s reading is into Y chromosome DE, so I’ m chasing down papers that can help me figure out the earliest out of Africa Y chromosome movements. It’s not looking like DE is East African in origin, although I think North Africa is possible given the distribtion of DE, E and D. I’m starting to suspect if the OOA populaiton movement was one swift sudden expansion. Did it stall for a while In NE Africa? I’m no longer buying the Gate of Tears as an OOA exit. Looking at other later population movements the Horn doesn’t seem to play any part in the movements from Eurasia and Africa until about 10k ago.