Human genetic diversity is shaped by both demographic and biological factors and has fundamental implications for understanding the genetic basis of diseases. We studied 938 unrelated individuals from 51 populations of the Human Genome Diversity Panel at 650,000 common single-nucleotide polymorphism loci. Individual ancestry and population substructure were detectable with very high resolution. The relationship between haplotype heterozygosity and geography was consistent with the hypothesis of a serial founder effect with a single origin in sub-Saharan Africa. In addition, we observed a pattern of ancestral allele frequency distributions that reflects variation in population dynamics among geographic regions. This data set allows the most comprehensive characterization to date of human genetic variation.
Posted in plenty of other places, but I thought I’d get around to it.
Most interesting observations from my POV are the European trace in the Uygur and in Mongolia- I would have expected central Asian purely from proximity. It also shows the Kalash are typically central Asians for alll the light hair and eyes you see in them. The Mozabite show as mainly near eastern, which is hardly surprsing as that’s where most of their maternal ancestry comes from. Transit across the Med seems to be about twice as much as much as the contributions from the African cluster. Not surprising to me is the trace middle Eastern ancestry in the Bantu samples, as I know mt DNA U is seen in them occassionally.
If you take a really close look at the American Maya samples you can see a slight trace of Oceanian blue. The European trace can be put down to recent mixture, but the Oceanian-I don’t think so. A trace remant of the older australoid population maybe.