The X chromosome in population genetics

The X chromosome in population genetics

Something I’m posting a link to for later reference, in case I see any more X chr studies. The bit I want to find quickly is…

Taken together, these studies indicate an Out of Africa origin for modern humans. Individually, however, the studies point to diverse conclusions. For example, two studies reconstructed haplotypes in introns of X chromosome-linked genes, using chromosomes drawn from many populations around the world. The first study7 found a pattern that was strongly indicative of a recent expansion (and subsequent isolation by distance) of humans from a single geographical source. The chromosomes showed two common, old (200,000–800,000 years) haplotypes with worldwide distribution, as well as many younger, derived haplotypes (~100,000 years old) with limited geographical distribution.Africa was identified as the probable source for the expansion on the basis of the higher genetic diversity there, and by the continued presence of the ancestral human haplotype (as  determined by comparison with other primates). The second study44, on the other hand, found a pattern that was more consistent with multiregionalism.

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