Tag Archives: metabolism

Mitochondrial Haplogroup N9a Protects Against Metabolic Syndrome

Women With Mitochondrial Haplogroup N9a Are Protected Against Metabolic Syndrome
To identify mitochondrial haplogroups that confer resistance against or susceptibility to metabolic syndrome, we performed a large-scale association study on 1,337 unrelated Japanese individuals, including 871 subjects with metabolic syndrome and 466 control subjects. Metabolic syndrome was diagnosed according to modified National Cholesterol Education Program Adult Treatment Panel III guidelines, using the cutoff point for obesity as a BMI of 25 kg/m2 instead of waist circumference. The genotypes for 25 polymorphisms in the coding region of the mitochondrial genome were determined, and the haplotypes were classified into 10 major haplogroups, i.e., F, B, A, N9a, M7a, M7b, G1, G2, D5, and D4. Multivariate logistic regression analysis revealed that the haplogroup N9a was significantly associated with resistance against metabolic syndrome in women with an odds ratio (OR) of 0.21 (95% CI 0.07–0.58, P = 0.0042). Women with haplogroups G1 and D5 tended to be resistant against metabolic syndrome with an OR of 0.22 (0.06–0.68, P = 0.0129) for G1 and with an OR of 0.32 (0.10–0.96, P = 0.0469) for D5, respectively. These results indicate that mitochondrial haplogroup N9a may be a protective factor against metabolic syndrome in Japanese women.

A hunters metabolism

Reading some of my research just hammers it home how recent an addition to the diet grains are, specifically for people who are not from the middle East, or from populations that have been hunter gatherers until Europeans turned up. Yet still, you see them pushed as the base of the food pyramid, in spite of all the evidence that that bulk carbs cause real health problems. I continually see ‘saturated fat and meat causes heart attacks’, which is a terrible half truth. The real truth is that partially hydrogenated fats (the got lumped in with saturated in the early studies) cause heart attacks, but saturated fats don’t, unless they are from corn fed meat.This is an important distinction, because corn fed meat contains a lot of omega six oils, and an imbalance in the O6 an O3 oils has been shown to cause heart problems. The O6 inhibits the metabolism of O3 oils (as does high blood insulin levels), and leads to problems like inflammation of the blood vessels, a major cause of cholesterol deposition in arteries. Incidentally, the same problem applies to vegetarian sources of O3 oils, and they also don’t contain the must crucial form of O3 oils, the kind the find in fish and hunted meat. Hunted meat has a very healthy fat content, and should never be equated to corn fed meat in dietary studies, it’s lipid profile isn’t unlike fish.There’s a bunch of studies that show low carb diets improve your cholesterol levels, but they never get much publicity, some very heavy hitters (medically) have come down supporting low carb diets as good for the health of a lot of people.


You know, I’ve never seen a study claim that fish or shellfish are unhealthy, barring mercury contamination. Yet Vegetarians still insist they live longer for not eating it. This is a lie, as several lifestyle adjusted studies show people who eat a lot of fish live longest of all. No studies ever show hunter gatherers as having a high rate of cancer or heart disease, and several groups eat non stop meat

I’m sure vegetarians have some bizarre image of humans throughout our evolution eating only nuts, grains, fruits and starchy roots. We ate no grain for a large part of our evolution, as grains require a lot of processing before we can eat them, and I don’t think homo erectus was known for owning querns. There’s a lot of evidence we ate… a lot of meat, fish, nuts, seeds, small fruits like berries, green vegetables, and some starchy roots. The meat/fish consumption of UK hunter gatherers was as much as 70% of their calories in the stone age. (Trent woman). Sugar and grain were not in evidence, and most hunter gatherer groups known in modern times ate naff all in the way of grains. Bulk carbs and big sugary fruits are a product of our very recent foray into agriculture, and a lot of us don’t handle a farmers diet well. About 40% of us, in the UK. My own metabolic quirks, like a ruthlessly high requirement for animal purines, and insulin resistance, are markers for a hunting ancestry not farming, very Mesolithic. Anyone who’s ever done a survival course in the woods will tell you, carbs are a rarity. There’s plenty of bunnies and green veg though.

This might be a more practical move by politicians, as the planet is over populated right now, and you couldn’t feed everyone the optimum diet if you wanted to. I also suspect the medical authorities that advise the American population would get sued blind if they reversed their guidelines. they’ve also built their reputations on ‘fat is bad’. PETA was have a fit, as would all those other vegetarian groups. All those companies that make low-fat food and the diet industry would go bankrupt, and the pharmaceutical companies make billions off diseases caused by our diet. I’m never really one for conspiracy theories, but this one has probably got some truth to it.